Sensation Seeking, Mania, and Monoamines

Vol. 13, No. 3, 1985

Free Abstract Article (PDF 4512 KB)

Biological Psychology/Pharmacopsychology

Sensation Seeking, Mania, and Monoamines
Marvin Zuckerman

Department of Psychology, University of Delaware, Newark, Del., USA

Address of Corresponding Author

Neuropsychobiology 1985;13:121-128 (DOI: 10.1159/000118174)

Key Words

Personality
Sensation seeking
Affective disorders
Monoamines
Catecholamines
Gonadal hormones
Monoamine oxidase
Norepinephrine (noradrenaline)
Dopamine
Serotonin

Abstract

Mania is a clinical state that could be described as sensation seeking behavior out of control. This article describes the biochemical correlates of the sensation seeking trait in normals including: gonadal hormones, monoamine oxidase, CSF norepinephrine, plasma dopamine-beta-hydroxylase and serotonin. The findings on monoamines and their neuroregulators in manic and depressed states of bipolar affective disorders are also discussed. Some hypotheses are suggested that link the personality disposition with the variations in the clinical state, and make some high sensation seekers 'at risk' for the affective disorder.

Author Contacts

Prof. M. Zuckerman, College of Arts and Science, Department of Psychology, University of Delaware, Newark, DE 19716 (USA)

Article Information

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